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Your Questions For Our Resident Expert

What are DNA/RNA hybrid oligos used for, and can IDT synthesize them?

DNA/RNA hybrids are most commonly used in RNA silencing applications where DNA bases are placed on the ends of an siRNA molecule to decrease degradation within the cell.

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When should I choose PAGE vs HPLC purification?

IDT recommends PAGE purification for long unmodified oligos and oligos used in cloning, gel shift, and mutagenesis protocols.

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How do I reorder an oligo?

For IDT orders placed through the web, reorder items via Order History.

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Where do I find my QC data?

If you placed your IDT order through the web, quality control documents will be uploaded to your web account.

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When do researchers use random (mixed) base oligos? Can I get custom ratios of the random bases incorporated?

Mixed bases are used in primers to bind to templates that contain variability or a mixture of sequences at the primer binding sites.

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