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Nano-delivery of DsiRNAs results in improved gene silencing and anticancer activity

Liu X, Liu C, et al. (2014) Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system. Nanomedicine, 10(8):1627–1636.

Citation summary: Find out how a dendrimer-based, targeted nano-delivery system that uses Dicer Substrate RNAs (DsiRNAs) leads to improved gene silencing and anticancer activity in prostate cancer models in vitro and in vivo.

Mar 23, 2015

Revised/updated Oct 7, 2015

Liu and colleagues have developed an siRNA delivery method that addresses 2 major challenges of using RNA interference for treating diseases: increasing siRNA potency and providing more targeted delivery. Working with in vitro and in vivo model systems for prostate cancer, the scientists used a dendrimer-based, targeted nano-delivery system to transport Dicer Substrate RNAs (DsiRNAs) into PC-3 cells and nude mice bearing PC-3 prostate cancer xenografts. Coupling this delivery mechanism with DsiRNAs resulted in a much greater RNAi response and, thus, improved therapeutic efficacy, than when conventional siRNAs were used. Further decoration of the DsiRNA/dendrimer complexes with a peptide that simultaneously promotes cancer cell targeting and penetration, led to improved gene silencing and anticancer activity in prostate cancer models in vitro and in vivo.

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