Frequently asked questions

Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.

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How do you recommend assessing off-target effects?

To avoid problems with coverage using in-cell techniques, we recommend initial screening for off-target effects using cell-free methods, such as circle-seq or site-seq. Guide-seq is one unbiased live-cell method to consider. Bioinformatics-based methods for predicting off-target sites are not sufficiently comprehensive.