Frequently asked questions

Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.

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Where should I place phosphorothioate bonds to increase stability of my oligo?

Including 3–5 nucleotides with phosphorothioate bonds at the 3' and 5' ends of your oligo can inhibit exonuclease degradation. Including phosphorothioate bonds throughout the entire oligo will help reduce attack by endonucleases as well.

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