What is the expected reduction in off-target effects (OTEs), when using Alt-R® S.p. HiFi Cas9 Nuclease 3NLS?

Jul 31, 2017, 06:00 AM
In many cases, Alt-R S.p. HiFi Cas9 Nuclease 3NLS exhibits a 10–20 fold reduction in editing at problematic off-target sites, when compared with the standard Alt-R S.p. Cas9 Nuclease 3NLS. The amount of reduction in off-target editing is highly variable and can differ based on multiple factors, including off-target site, ribonucleoprotein (RNP) dose, and cell type.
  • Genome Editing
  • Genome Editing
  • Alt-R
  • Cas9