Top Questions

Is it possible to order an oligo with both an amino modifier modification and a modification attached via NHS Ester chemistry?

Unfortunately, we are not able to provide oligos with both a free amine and an NHS ester modification. The NHS ester will bind to any free amino group as it is attached to the oligo post synthesis. IDT recommends using a modification that is attached via a different chemistry, such as Click chemistry or phosphoramidite chemistry.
Tags:
  • Click chemistry
  • NHS ester
  • amine
Product Support Topics