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When performing NGS, when is enrichment/target capture of genomic sequences necessary?

You should consider target enrichment (target capture) if you are analyzing a subsection of the genome or performing deep sequencing to detect rare mutations. This allows you to re­serve sequencing capacity for the region(s) of interest, and reduce the sequencing cost and time associated with data analysis. IDT xGen™ Lockdown™ Probes are useful for enriching genomic regions ≤250 kb. They are also excellent for supplementing other capture panels to expand the target region or improve enrichment performance.

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