IDT Publications - RNAi: miRNA, lncRNAs, and AMOs

This bibliography contains a list of research papers published by IDT scientists (bold). Click on the reference to read the PubMed abstract, or entire paper, if published in an open access journal. Otherwise, you will be able to obtain a PDF download of the paper through the PubMed site.

  1. Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A, Ghazal P. (2016) An interferon regulated microRNA provides broad cell-intrinsic antiviral immunity through multihit host-directed targeting of the sterol pathway. PLoS Biol, 14(3):PMID: 26938778.
  2. Lennox K, Behlke M. (2015) Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides. Nucl Acids Res, 1093:863–877.
  3. Sarvestani ST, Stunden HJ, Behlke MA, Forster SC, McCoy CE, Tate MD, Ferrand J, Lennox KA, Latz E, Williams BRG, Gantier MP. . (2015) Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors. Nucl Acid Res, 43:PMID:25539920; doi: 10.1093/nar/gku1343.
  4. Lennox KA, Owczarzy R, Thomas DM, Walder JA, and Behlke MA. (2013) Improved performance of anti-miRNA oligonucleotides using a novel non-nucleotide modifier. Molec Ther Nucleic Acids, 2:e117; doi:10.1038/mtna.2013.46.
  5. Ramachandran S, Karp PH, Osterhaus SR, Jiang P, Wohlford-Lenane C, Lennox KA, Jacobi AM, Praekh K, Rose SD, Behlke MA, Xing Y, Welsh MJ, McCray PB Jr. (2013) Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs. Am J Respir Cell Mol Biol, 49(4):544–551.
  6. Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL. (2013) Altered Purkinje cell miRNA expression and SCA1 pathogenesis. Neurobiol Dis, 54:456–463.
  7. Gantier MP, Stunden HJ, McCoy CE, Behlke MA, et al. (2012) A miR-19 regulon that controls NF-kB signaling. Nucleic Acids Res, 40(16):8048–8058.
    miRNA antagonists (AMOs) to selected miR-19 family members  and Dicer-substrate siRNAs (DsiRNAs) targeting RNF11 and EGFP (target and control, respectively) are used in a study to show that targeting miR-19 and linked family members may regulate NF-kappaB signalling in inflammation.
  8. Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD. (2012) Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA, 18(11):2041–2055.
  9. Kredo-Russo S, Mandelbaum AD, Ness A, Alon I, Lennox KA, Behlke MA, Hornstein E. (2012) Pancreas-enriched miRNA refines endocrine cell differentiation. Development, 139(16):3021–3031.
  10. Munoz-Alarcon A, Guterstam P, Romero C, Behlke MA, Lennox KA, Wengel J, El Andaloussi S, Langel U. (2012) Modulating anti-microRNA-21 activity and specificity using oligonucleotide derivatives and length optimization. ISRN Pharm, :e407154.
  11. Ramachandran S, Karp PH, Jiang P, Ostedgaard LS, Walz AE, Fisher JT, Keshavjee S, Lennox KA, Jacobi AM, Rose SD, Behlke MA, Welsh MJ, Xing Y, McCray PB Jr. (2012) A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA, 109(33):13362–13367.
  12. Devor EJ, Huang L, Wise A, Peek AS, Samallow PB. (2011) An X chromosome MicroRNA cluster in the marsupial species Monodelphis domestica. J Hered, 102(5):577–583.
  13. Lennox KA, Behlke MA. (2011) Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther, 18:1111–1120.
  14. Gantier MP, McCoy CE, Rusinova I, Saulep D, Wang D, Xu D, Irving AT, Behlke MA, Hertzoq PJ, Mackay F, Williams BR. (2011) Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res, 39(13):5692–5703.
  15. Melkman-Zehavi T, Oren R, Kredo-Russo S, Shapira T, Mandelbaum AD, Rivkin N, Nir T, Lennox KA, Behlke MA, Dor Y, Hornstein E. (2011) miRNA control insulin content in pancreatic β-cells via downregulation of transcriptional repressors . EMBO J, 30(5):835–845.
  16. Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE. (2011) Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab, 14(1):33–44.
  17. Lennox KA, Behlke MA. (2010) A direct comparison of anti-microRNA oligonucleotide potency. Pharm. Res, 27(9):1788–1799.
  18. Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL. (2010) Structure and activity of putative intronic miRNA promoters. , 16(3):495–505.
  19. Devor EJ, Peek AS, Lanier W, Samollow PB. (2009) Marsupial-specific microRNAs evolved from marsupial-specific transposable elements. Gene, 448(2):187–191.
  20. Devor EJ, Huang L, Samollow PB. (2008) PiRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets . Mamm Genome, 19(7):581–586.
  21. Devor EJ, Peek AS. (2008) MiRNA profile of a Triassic common mammalian ancestor and pre-miRNA evolution in the three mammalian reproductive lineages . The Open Genomics J, 1(1):22-32.
  22. Devor EJ, Samollow PB. (2008) In vitro and in silico annotation of conserved and nonconserved microRNAs in the genome of the marsupial Monodelphis domestica. J Hered, 99(1):66-72.
  23. Abdurakhmonov IY, Devor EJ, Buriev ZT, Huang L, Makamov A, Shermatov SE, Bozorov T, Kushanov FN, Mavlonov GT, Abdukarimov A . (2008) Small RNA regulation of ovule development in the cotton plant, G. hirsutum L . BMC Plant Biol, 8:93.
  24. Lee NS, Kim JS, Cho WJ, Lee MY, Steiner R, Gompers A, Ling D, Zhang J, Saetrom P, Behlke M, Moon SH, Salvaterra PM, Jove R, Kim KS. (2008) miR-302b maintains “stemness” of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. Biochem Biophys Res Commun, 377(2):434–440.
  25. Devor EJ. (2006) Primate microRNAs miR-220 and miR-492 lie within processed pseudogenes. J Hered, 97(2):186–190.