The N6-Methyl deoxyAdenosine (N6-Me-dA) modification consists of a methyl group at the nitrogen-6 position of a DNA base. It is a precursor of N6-methyl-2′-deoxyadenosine 3′, 5′-bisphosphate (N6MABP), a competitive antagonist specific to the P2Y1 receptors in the P2Y receptor family (see the below sidebar, P2Y receptors<\/strong>, to learn more). N6-Me-dA is useful in pharmacologic and research applications that examine the effects of selective inhibition of P2Y1 receptors, which appear to play a role in blood clotting.<\/p>\n N6-Me-dA is available from IDT as an “off-catalog” oligonucleotide modification on the 5′ base (\/5N6Me-dA\/) or an internal base (\/iN6Me-dA\/). Off-catalog modifications can be ordered through the website and are offered with yield and purity guarantees.<\/p>\n To order, enter your sequence online, placing the IDT ordering symbol in the desired location within your sequence. You can request N6-Me-dA oligonucleotides with standard desalt or HPLC purification. <\/p>\n See what other modifications are available from IDT. You can find a list of standard modifications we make to oligonucleotides on the Modifications page <\/a>of our online catalog. And if you don’t find what you are looking for, just send us a request. We often synthesize special, non-catalog requests. Contact us at noncat@idtdna.com<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":" Quick facts: Availability: DNA; can be ordered on an RNA oligo Location: 5′ and internal Scale: 100 nmol to large scale Purification: Standard desalt or HPLC IDT ordering symbol: \/5N6Me-dA\/ or \/iN6Me-dA\/ Figure 1. N6-Methyl deoxyAdenosine (N6-Me-dA). N6-Methyl deoxyAdenosine (N6-Me-dA) The N6-Methyl deoxyAdenosine (N6-Me-dA) modification consists of a methyl group at the nitrogen-6 position of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ct_builder_shortcodes":"","ct_template_type":"","ct_parent_template":0,"inline_featured_image":false,"footnotes":""},"class_list":["post-909","post","type-post","status-publish","format-standard","hentry"],"acf":[],"yoast_head":"\n![\"art66-MH-N6Me-dA-Fig1\"](\"https:\/\/www.idtdna.com\/page\/wp-content\/uploads\/idt-images\/199c5d15-3279-6e2e-aa53-ff00001c1b3c-art66-mh-n6me-da-fig1.png\" "\\"D-OLI15PS-n6methyladenosine-F1\\"")
N6-Methyl deoxyAdenosine (N6-Me-dA)<\/h3>\n
Order N6-Me-dA as an off-catalog modification <\/h3>\n
Learn about other modifications to facilitate your research <\/h3>\n