Introducing foreign RNA via transfection can affect cells in unforeseen ways, such as induction of an immune response in mammalian cells. Therefore, it is crucial to have an appropriate negative control against which one can compare experimental results in gene silencing and functional studies using DsiRNA duplexes. To this end, IDT has developed a negative control duplex (DS NC1) that does not target any part of the human, mouse, or rat transcriptomes. This duplex sequence serves as an ideal universal negative control for DsiRNA transfections in these organisms. The DS NC1 is available at 1 and 5 nmole scales. To order, go to www.idtdna.com.