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Frequently asked questions
Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.
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What is the purpose of ASOs modified in a gapmer format?
Gapmer antisense oligonucleotides (ASOs) include modified bases at each end of the Antisense Oligo (such as 2’MOE or Affinity Plus modified bases) with an internal stretch of unmodified DNA bases. The terminal modified bases can help to enhance stability and increase binding affinity to the target. The internal unmodified DNA bases are necessary to enable RNase H to bind to and cleave the RNA target.