Your product is now available from Integrated DNA Technologies.
Many of the Swift products you have grown to love are now part of our new complete portfolio, xGen™ NGS. Through this new partnership we are pleased to offer you comprehensive next generation sequencing solutions.
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Find Archer now at IDT!
All Archer information is now available on IDT’s website. You can view Archer assays alongside IDT’s xGen™ NGS portfolio to find the best next generation sequencing solution for your lab.
Confidently detect more with Archer NGS assay solutions for your solid tumor, blood cancer, immune profiling, and genetic disease research.
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Frequently asked questions
Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.
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What types of modifications are routinely used in antisense experiments?
Phosphorothioate (PS) bonds are added to antisense oligonucleotides to protect them from nuclease degradation. Antisense oligos can include a full PS backbone; however, the Tm decreases with each PS bond added. Including extensive PS modification can also promote the antisense oligo to non-specifically bind to proteins. This characteristic can increase oligo circulation time and improve cellular internalization when a delivery tool is not employed. However, it can also cause a pro-inflammatory response if the antisense oligo binds non-specifically to immune receptors.
5-Methyl dC (5-Me dC) modified bases are often used to prevent CpG motifs in an antisense oligo from triggering a TLR9 innate immune response. 2’-O-methoxy-ethyl (2’-MOE) or Affinity Plus locked nucleic acid base modifications are often added to increase nuclease resistance and binding affinity of antisense oligos.