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IDT offers several different options for Biotin modifications. For most applications, you will want either standard Biotin, which has a C6 spacer arm, or Biotin-TEG, which has an extended 15 atom tetra-ethyleneglycol spacer arm. The additional spacer arm length reduces steric hindrance when the bioin-modified oligo is to be attached to a solid surface, such as a streptavidin bead.
Read about our biotin modifications and their recommended applications in the DECODED article, Which biotin modification to use?