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Frequently asked questions

Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.

Will an oligo degrade between the time it is shipped and delivered?

Oligos in their dry state are stable for several months and should undergo no measurable degradation during their time in transit, even in the case of delays. Resuspended oligos are less stable than those left dry, however. Oligos stored dry, or in non-DEPC treated water for that matter, are very stable for the short period of time it takes to ship an oligo. IDT ships its oligos dry to provide the researcher complete control over the reagents they want to use for resuspension.(Any oligo that could potentially degrade while in transit will be shipped frozen.)

For long term storage, temperature is the most important factor to consider. For long term storage, whether oligos are dried down, or resuspended in water (non-DEPC treated) or TE Buffer (10 mM Tris pH 8.0, 0.1 mM EDTA; such as IDTE), it is optimal to store them frozen at -20°C. For room temperature or 4°C storage, oligos that are resuspended in TE buffer are more stable than dry oligos. Oligos that are stored in water are the least stable. However, at 4°C oligos stored under all of these conditions are stable for at least 60 weeks.

Please see the Technical Report, Oligonucleotide Stability Study for data on oligonucleotide storage and a more thorough explanation.

Custom DNA & RNA

*RUO—For research use only. Not for use in diagnostic procedures. Unless otherwise agreed to in writing, IDT does not intend for these products to be used in clinical applications and does not warrant their fitness or suitability for any clinical diagnostic use. Purchaser is solely responsible for all decisions regarding the use of these products and any associated regulatory or legal obligations.