Delivering Comprehensive Genomic Profiling for Clinical Cancer Care

Scientists at Foundation Medicine, Inc. are leading a transformation in cancer care by helping clinicians to select appropriate treatment options for each patient, informed by a thorough understanding of the molecular changes specific to their disease. Read about the use of xGen® Lockdown® Probes in their flagship FoundationOne® Test.

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She Prefers Red—Guppy Mate Preference

Scientists from Simon Fraser University (British Columbia, Canada) use guppies as a model to study the evolution of female mate preferences for male coloration. Read more about their field study using PrimeTime® qPCR Assays, ZEN™ Double-Quenched Probes, and gBlocks® Gene Fragments.

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Understanding How Distal Regulatory Elements Control Gene Expression

Based on Chromosomal Conformational Capture technology, Capture-C, a method developed by the Hughes laboratory (Oxford University, United Kingdom), allows researchers to isolate distal regulatory elements that interact with specific promoters in 3 dimensional space. By combining Capture-C with target capture using IDT xGen® Lockdown® Probes, and next generation sequencing, the researchers can interrogate the regulatory landscapes of hundreds of genes in a single experiment.

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Improving Immuno-PCR by Optimizing Antibody-Oligo Conjugation

Immuno-PCR, a modified antigen detection method, uses an antibody coupled to DNA, which is then amplified using real-time PCR. The method can significantly increase antibody-target detection sensitivity by 100–10,000X over standard ELISA assays. Innova Biosciences provides both a kit and a service to generate the antibody-oligonucleotide conjugates, and affirms that the high quality of IDT oligos provides optimal conjugation.

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Color-Changing Flowers—Biotechnology for Everyone

A start-up synthetic biology company is bioengineering color-changing flowers to capture the imagination of the general public and make genetically modified organisms (GMOs) more accessible, personal, and better understood.

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