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What is the sodium salt exchange for that is done post HPLC purification?

Jul 25, 2013, 21:36 PM
The sodium salt exchange we perform is a sodium acetate precipitation. It helps remove any remaining TEAA in the oligo preparation after HPLC purification.  It is important to make sure oligos used in vivo assays are TEAA-free because it can be toxic to cells.
Categories:
  • Purifications
Tags:
  • hplc
  • Sodium Salt Exchange