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Molecular Beacons

Prices below include synthesis of a custom oligo (up to 45 bases in length), reporter, quencher, and HPLC purification. Turnaround time is 5–7 business days for standard Molecular Beacons. 

Documentation and Support

5' Reporter DyeQuencherSynthesis ScaleMin GuaranteePrice
5' 6-FAM™3' Dabcyl250 nmole10 nmoles$440.00 USD
1 µmole40 nmoles$635.00 USD
3' Black Hole Quencher® 1250 nmole10 nmoles$470.00 USD
1 µmole40 nmoles$690.00 USD
3' Iowa Black® FQ250 nmole10 nmoles$405.00 USD
1 µmole40 nmoles$595.00 USD

5' Reporter DyeQuencherSynthesis ScaleMin GuaranteePrice
5' HEX™3' Iowa Black® FQ250 nmole10 nmoles$500.00 USD
1 µmole40 nmoles$660.00 USD

5' Reporter DyeQuencherSynthesis ScaleMin GuaranteePrice
5' TET™3' Iowa Black® FQ250 nmole10 nmoles$475.00 USD
1 µmole40 nmoles$690.00 USD

5' Reporter DyeQuencherSynthesis ScaleMin GuaranteePrice
5' TYE™ 5633' Iowa Black® RQ-Sp250 nmole5 nmoles$525.00 USD
1 µmole20 nmoles$760.00 USD

5' Reporter DyeQuencherSynthesis ScaleMin GuaranteePrice
5' TYE™ 6653' Iowa Black® RQ-Sp250 nmole5 nmoles$515.00 USD
1 µmole20 nmoles$780.00 USD

Molecular Beacons are a special class of dual-labeled probes having self-complementary ends that form a stem-loop structure (hairpin) in their native state. The hairpin forces the reporter and quencher into contact (dark). Upon hybridization to target, reporter and quencher are separated and the Molecular Beacon becomes bright. Because the hairpins in these probes result in enhanced specificity for their targets, Molecular Beacons are often better able to discriminate single nucleotide polymorphisms (SNPs) than simple linear probes [1].

Reference

  1. Thermodynamic basis of the enhanced specificity of structured DNA probes. Bonnet et al. proc Natl Acad Sci USA 96:6171-6176 (1999).