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Frequently asked questions

Our Scientific Applications Support team has assembled a list of frequently asked questions to help you find answers quickly. Filter using one or more categories to focus on specific topics, or use the search bar to perform a text search.

What makes Alt-R® S.p. HiFi Cas9 Nuclease 3NLS a high fidelity enzyme?

Alt-R S.p. HiFi Cas9 Nuclease 3NLS contains proprietary mutations that reduce cutting at problematic off-target sites, while maintaining similar on-target potency.