Discovery to clinic: Comprehensive solutions for every stage of your CRISPR program
Explore our full spectrum of customizable CRISPR reagents for a range of applications from basic research to therapeutic applications—all backed by expert support for success at every stage .
Early discovery solutions
Our Research Use Only (RUO) solutions provide the flexibility and precision needed to drive early-stage CRISPR research.
- Custom gRNAs (predesigned, custom gRNAs, and CRISPR libraries)
- CRISPR-Cas nucleases, including HiFi Cas9 and Cas12a Ultra
- Modified HDR donor templates and enhancer for precise genomic changes with high HDR rates
Preclinical solutions
Our scalable manufacturing and robust quality control processes support preclinical studies with consistent and reliable products.
- HPLC-purified, guide RNA production with increased scalability
- Optimized donor templates for complex genome editing needs
- Safety services (off-target analysis)
- Process development support to prepare for clinical manufacturing
Therapeutic solutions
Our GMP/CGMP-compliant* manufacturing services ensure the highest quality reagents for clinical applications.
- Single vendor solution for your therapeutic development
- CGMP guide RNA manufacturing with full traceability and documentation compliant with ICH Q7 guidelines
- CGMP Cas nucleases through our strategic partnership with Aldevron
- Regulatory support for Investigational New Drug (IND) submission and Clinical Trial Applications (CTA)
- Scalable production to meet clinical trial needs
From the lab to life-changing advances
Read how IDT and Aldevron manufactured the world's first mRNA-based personalized CRISPR therapy
Early discovery
- High-throughput screening
- Target identification
- Lead discovery
- Basic gene function research
Preclinical
- Lead validation
- In vitro model generation (T cells, iPSCs models)
- In vivo model generation: Animal models
- Regulatory considerations & IND/CTA filings
- Off-target safety testing
Clinical
- CGMP manufacturing
- Post IND/CTA regulatory support
Empower your genome editing
Empower your genome editing from design-to-analysis with our complete CRISPR workflow. Alt-R™ optimized Cas9 and Cas12a systems, customizable gRNAs, HDR solutions, and analysis tools that are backed by expert support for success at every stage.
Discovery to preclinical research solutions
Guide RNAs
- Cas9 guide RNA
- Cas12a guide RNA
- Custom guide RNAs (pegRNA, Cas13 etc)
- Guide RNA libraries
Cas enzymes
HDR reagents
Therapeutic (clinical) application solutions
Accelerate your CRISPR therapeutic development with our CGMP gRNA manufacturing service, CGMP Cas enzymes, safety services, and regulatory support for your IND and CTA filings. Our end-to-end services ensure compliance, efficiency, and a faster path to clinical trials.
CGMP manufacturing services
IND-enablement services
- Safety services (off-target editing analysis)
- gRNA sequencing services (coming soon!)
- Regulatory Affairs support services
Enabling real-world impact
Learn more about how our partnerships are fueling critical discoveries
Why choose Integrated DNA Technologies?
- Integrated solutions: A complete workflow from research to clinical application
- Expert guidance: Technical, regulatory, and project management support
- Proven quality and reliability: Trusted manufacturing processes with robust quality control
Key benefits for CMC managers
- Fast turnaround: Accelerate your timeline with streamlined manufacturing processes
- Trusted support: Partner with experienced professionals for technical and regulatory guidance
- Early partnership: Collaborate with IDT to mitigate risks and optimize processes early in development
- Cost efficiency: Reduce costs through IDT's integrated solutions and scalable manufacturing capabilities
Supporting your IND submission and beyond
Our RUO to CGMP services are designed to support your IND application with comprehensive documentation, data packages, and regulatory support.
*GMP or Good Manufacturing Practices are regulation enforced by the FDA in the United States. CGMP refers to Current Good Manufacturing Practices emphasize continual quality advancements based on current technologies and industry standards.