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Custom RNA Oligos

IDT has the expertise to deliver custom-synthesized RNA with the yield and purity that today's researcher demands. RNA is shipped deprotected and desalted in 2–3 business days or deprotected and purified in 4–6 business days. Please inquire for turnaround on 5 µmole and 10 µmole RNA synthesis.



Documentation and Support

Single Entry

Single Entry Enter modified sequences and more complex structures,
one at a time.

Multiple Entry

Multiple Entry Number of Items:   

Excel or Text Paste Entry

Excel or Text Paste Entry Paste multiple sequences from Excel or a text file directly into the website.

Duplex Entry

Duplex Entry Enter duplexed RNA, one duplex at a time.

Available Lengths: RNA oligos are available from 10–90 bases for 100 nmole, 5–90 bases for 250 nmole and 1 µmole, and 5–50 bases for 5 µmole and 10 µmole.

Description100 nmole RNA Oligo250 nmole RNA Oligo1 umole RNA Oligo5 umole RNA Oligo10 umole RNA Oligo
RNA bases$6.50 USD$8.50 USD$18.00 USD$60.00 USD$115.00 USD
2' O-Methyl RNA bases$8.50 USD$13.50 USD$20.00 USD$85.00 USD$160.00 USD
Chimeric DNA bases$0.60 USD$1.00 USD$2.10 USD$11.50 USD$20.00 USD
RNase Free HPLC Purification$75.00 USD$105.00 USD$160.00 USD$340.00 USD$590.00 USD

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2′-O-methyl RNA is a useful RNA analog that is resistant to degradation by single-stranded ribonucleases. To include a 2’ O-methyl modification in your RNA sequence, simply place a lowercase "m" in front of the base; for example, mAmGmCmU.

2′-O-methyl RNA

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RNA, RNA analogs and chimeras are available in quantities up to ten grams.  IDT continues the tradition of providing researchers with the highest quality RNA oligonucleotide synthesis, in quantities ranging from multi-mg to several grams.

Large-Scale RNA Synthesis

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  • Target validation and development programs for siRNA, DsiRNA, aptamers, ribozymes, antisense and others
  • Extensive QC packages tailored to researchers' needs
  • Sterile-filtered oligo preparations available, endotoxin free
  • Harmonized protocols allow simple transfer to our kilo-scale cGMP manufacturing partner
  • Contact Customer Service for more information

Custom Services

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Generally for RNA oligos, 1 OD260 ≈ 100/x nanomoles, where x is the length of the oligos in bases. For the average 20mer RNA oligo, 1 OD = 5 nmoles.  Actual nanomoles per OD varies with sequence composition.

To learn more about what else makes RNA unique, click here.

Technical Notes

IDT Guarantees Quality

IDT has pioneered the use of high throughput quality control methods. We are the only oligonucleotide manufacturer that offers purity guarantees and 100% QC by electrospray ionization (ESI) mass spectrometry, ensuring that only the highest quality products are shipped to our customers. We also offer capillary electrophoresis (CE) and analytical HPLC as routine tools for additional QC on purified sequences. In addition to DNA, IDT has led the effort over the last decade to reduce the cost of high-quality custom RNA synthesis. Through improvements to the traditional tert-butyldimethylsilyl (tBDMS) chemistry and advances in instrumentation, IDT has achieved the highest coupling efficiency in the industry. Only at IDT are customers guaranteed the very best in quality synthesis with free mass spectrometry and CE traces on all purified oligos.